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Homologous genes within a species are called paralogs.

A) True
B) False

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The short arm of a chromosome is denoted by the letter ________ and the long arm by the letter ________.


A) p, q
B) s, l
C) q, p
D) c, d

E) B) and D)
F) None of the above

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The African clawed frog (Xenopus laevis) is allotetraploid, likely as a result of an interspecies mating long ago, followed by a duplication of the entire genome. Xenopus laevis is fertile and has a normal life cycle. In contrast, mules, the allodiploid offspring of a male donkey and a female horse, are generally sterile. Why can Xenopus reproduce and mules cannot?


A) Frogs are less sensitive to multiple copies of the genome than mammals.
B) In allotetraploid organisms each chromosome has a chromosome to pair up with in meiosis, whereas in allodiploid organisms they do not.
C) The two frogs that interbred to form the Xenopus laevis must have been more closely genetically related than the donkey and horse are.
D) The mule must have a genetic mutation that prevents it from reproducing.

E) B) and C)
F) None of the above

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The ends of chromosomes have areas of repeated DNA called centromeres.

A) True
B) False

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A photographic representation of the chromosomes of an organism is called a(n) ________.


A) allele variation
B) chromosomal spreading
C) chromosome picture
D) karyotype

E) A) and C)
F) A) and D)

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Given the following sequence of genes on a chromosome, determine what change in chromosome structure occurred. (the * indicates the centromere) before A B C D * E F G H After A C D * E F G H


A) Terminal deletion
B) Interstitial deletion
C) Inversion
D) Gene duplication

E) A) and B)
F) A) and C)

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SMAD4 is a tumor suppressor gene located on chromosome 18 that is known to be homozygously deleted in human lung cancer. If you were to perform comparative genomic hybridization using tissue from a lung cancer patient with a homozygous negative SMAD4 tumor, what ratio of green to red fluorescence would you expect?


A) A ratio of 1 on all of chromosome 18.
B) A ratio of 2 on the part of chromosome 18 containing the SMAD4 gene, with a value of 1 on the remainder of the chromosome.
C) A ratio of 0 on all of chromosome 18.
D) A ratio of 0 on the part of chromosome 18 containing the SMAD4 gene, with a value of 1 on the remainder of the chromosome.
E) A ratio of 1 on the part of chromosome 18 containing the SMAD4 gene, with a value of 0 on the remainder of the chromosome.

F) A) and C)
G) None of the above

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A wholphin is a rare hybrid animal born from mating a female bottlenose dolphin with a male false killer whale. Wholphins are diploid. Interestingly, wholphins are fertile. What can you conclude from the fact that wholphins are fertile?


A) Wholphins are allotetraploid.
B) Dolphins and false killer whales likely have the same number of chromosomes.
C) Dolphins and false killer whales are actually the same species.
D) One of the parents must have been aneuploid.

E) A) and C)
F) None of the above

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Due to the formation of an inversion loop, sections of DNA may either be duplicated or deleted depending on the size of the inversion.

A) True
B) False

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Given the following sequence of genes on a chromosome, determine what change in chromosome structure occurred. (the * indicates the centromere) before A B C D * E F G H After A B C D * E F E F G H


A) Terminal deficiency
B) Interstitial deficiency
C) Inversion
D) Gene duplication

E) A) and C)
F) B) and D)

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Polyploid plants tend to produce fewer fruits and flowers, be smaller in size, and not adapt as well to extreme environmental conditions as normal varieties.

A) True
B) False

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